We report a case of an acute ST-segment elevation myocardial infarction in a affected person with traditional cardiac threat components utilizing supraphysiologic doses of supplemental, intramuscular testosterone. In addition, this patient additionally had polycythemia, doubtless secondary to high-dose testosterone. The patient underwent successful percutaneous intervention of the best coronary artery. Physicians and sufferers ought to pay attention to the clinical penalties of anabolic steroid abuse. Development of an atheromatous plaque perpetuates endothelial dysfunction and promotes platelet aggregation and intracoronary thrombus formation (Ajayi et al 1995; Nieminen et al 1996).
Erythrocytosis has been reported as a potential impact of testosterone, which could be beneficial in sufferers with anemia. The best threat of erythrocytosis occurs with injectable forms of testosterone compared with transdermal preparations, especially in supraphysiologic doses. An enhance of up to 44% of the baseline hematocrit has been reported .
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Rhoden EL, Morgentaler A. Risks of testosterone-replacement therapy and recommendations for monitoring. Testosterone replacement in hypogonadal males with angina improves ischaemic threshold and high quality of life. Ajayi AAL, Mathur R, Halushka PV. Testosterone improve human platelet thromboxane A2 receptor density and aggregation responses.
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