AW and you may JC devised and prepared the study. AW written the fresh new manuscript. BC did study administration. BC and you may PN performed analytical analyses. AW and you can JC ensured endeavor and study management. All authors (AW, PN, ML, BC, TP, LD, ALB, IY, SFo, SFr, and JC) lead to interpretation of one’s analysis and you may modified the latest manuscript. All the article authors recognized the final manuscript. The newest corresponding journalist (AW) attests that every indexed writers fulfill writing requirements hence no others conference the new conditions had been excluded. AW and you can JC are the guarantors.
Funding: This study was financed of the French National Medical insurance danish chat room without registration Funds (CNAM) and also the Fitness Equipment Epidemiology Medical Interest Class (ANSM-CNAM EPI-PHARE SIG). AW, JC, and you may BC was personnel out of French National Medical insurance Funds, PN are a member of staff of one’s French National Agencies to possess Pills and you may Wellness Situations Defense. The current papers represents the new viewpoints of your own article authors and you may do never mirror the career of the companies.
Fighting passion: All the experts have completed new ICMJE uniform revelation setting at and you will declare: assistance of French National Medical health insurance Loans (CNAM) and the Wellness Device Epidemiology Medical Desire Category (ANSM-CNAM EPI-PHARE SIG) toward registered works; zero financial matchmaking with people enterprises which may have an interest regarding filed operate in the earlier three years; not one matchmaking otherwise issues that could appear to have influenced the brand new submitted really works.
The lead writer (AW) affirms this particular manuscript is actually a respectable, accurate and you can clear membership of the study are advertised; one zero important aspects of study were omitted; hence people inaccuracies throughout the analysis because the prepared (and you can, in the event that relevant, registered) was indeed told me.
Dissemination to players and you may relevant diligent and you will social groups: The outcomes was made available to patient relationship agents. Patients who had made use of cyproterone acetate milligrams along the previous several many years (and their standard practitioners) obtained a reports page at your home providing more information on what doing (supplementary situation S18).
Variety of accepted evidence into the girls and you will people and you will revenue out of highest dose cyproterone acetate (10 milligrams and you will 50 mg) by nation in the Europe
Research communities
One or two almost every other susceptibility analyses have been presented: studies of the 2007-14 launched or control classification chief cohort who have been matched up to own age at the initiation and duration of go after-right up, and a good nested circumstances-manage learn from this new 2007-fourteen fundamental cohort.
Overall performance
Chance, cousin risk, and you can modified possibility proportion from meningioma centered on exposure to cyproterone acetate (head cohort, 2007-14; n=253 777)
The fresh estimated number of people that have meningioma attributable to cyproterone acetate is over 500 within the France toward period 2007-15 (62 per year; supplementary point S16). This imagine is dependent on a conventional computation that will not make up people with a diagnosis one or more year immediately following discontinuation of cyproterone acetate, individuals with an analysis after a primary category of most somewhat unsealed (handle classification) and next resumption of cyproterone acetate, and you will meningiomas treated because of the scientific realize-right up instead of businesses otherwise radiation therapy.
On the other hand, the presence of progesterone receptors in the arachnoid tissue, of which meningiomas occur, could have been known for five ages.5556575859 Multiple authors enjoys said a good heterogeneous delivery of progesterone receptors with respect to the website out-of meningiomas. A good rostrocaudal gradient regarding progesterone receptors, with a higher density of receptors on skull ft, has actually often already been claimed, and is affirmed by several e-books.6061 Our very own shopping for off a predominance of anterior skull ft meningiomas linked to access to cyproterone acetate, an excellent progestogen, was in line with this type of physiological conclusions.
Advantages on the analysis
Several limits and matter new logical and you will histological services regarding meningioma. SNDS does not include research for the results of magnetized resonance imaging or histology, otherwise whether or not meningiomas try single or numerous, apart from businesses one to encompass type of anatomical countries.