AW and JC conceived and prepared the study. AW drawn up the fresh new manuscript. BC did analysis government. BC and you can PN performed analytical analyses. AW and you may JC made sure venture and study government. Most of the experts (AW, PN, ML, BC, TP, LD, ALB, IY, SFo, SFr, and you can JC) lead to translation of data and you may modified brand new manuscript. Most of the people approved the very last manuscript. This new corresponding publisher (AW) attests that detailed article writers fulfill authorship criteria and therefore zero anybody else fulfilling brand new criteria had been omitted. AW and you can JC are definitely the guarantors.
Funding: This study was funded because of the French Federal Medical health insurance Loans (CNAM) additionally the Wellness Product Epidemiology Scientific Desire Category (ANSM-CNAM EPI-PHARE SIG). AW, JC, and you can BC is employees out of French National Medical insurance Money, PN are an employee of the French National Department having Medications and you can Fitness Situations Safety. The present report means the newest feedback of your people and you may do not necessarily reflect the position of their companies.
Competing passion: All article authors have finished brand new ICMJE uniform revelation setting at the and you will declare: help out-of French National Medical health insurance Finance (CNAM) together with Fitness Product Epidemiology Scientific Desire Classification (ANSM-CNAM EPI-PHARE SIG) into recorded works; zero economic dating having one enterprises that might are interested about submitted work in the last three years; no other matchmaking or issues that may appear to have influenced the fresh new filed performs.
The lead copywriter (AW) affirms that manuscript is actually an honest, right and you can clear membership of 
studies being said; you to no key factors of one’s investigation was excluded; and this any inaccuracies throughout the studies as the arranged (and you can, if related, registered) was in fact said.
Dissemination in order to players and you can relevant diligent and you will personal organizations: The outcome was basically made available to diligent organization representatives. People who had put cyproterone acetate milligrams along the early in the day two years (and their standard practitioners) acquired a reports letter home providing more information about what to-do (secondary issue S18).
Set of acknowledged symptoms in people and you may people and you will purchases of higher dosage cyproterone acetate (10 milligrams and you can fifty milligrams) of the country during the European countries
Data communities
A few almost every other susceptibility analyses was basically presented: studies of 2007-14 unwrapped or control category chief cohort who have been matched to possess years in the initiation and lifetime of pursue-up, and you will a beneficial nested situation-control study from the new 2007-14 fundamental cohort.
Results
Frequency, cousin risk, and modified risk proportion away from meningioma considering contact with cyproterone acetate (main cohort, 2007-14; n=253 777)
The latest estimated number of people which have meningioma owing to cyproterone acetate are more than 500 for the France towards the months 2007-fifteen (62 a-year; second thing S16). So it imagine is based on a traditional calculation that will not account for individuals with an analysis multiple seasons immediately following discontinuation off cyproterone acetate, people with a diagnosis immediately after a primary class out of extremely somewhat started (handle category) and you will further resumption from cyproterone acetate, and you will meningiomas managed because of the scientific follow-upwards versus operations or radiotherapy.
At the same time, the existence of progesterone receptors inside the arachnoid cells, where meningiomas develop, might have been noted for five many years.5556575859 Multiple authors keeps stated an excellent heterogeneous shipment out of progesterone receptors according to the webpages out of meningiomas. A beneficial rostrocaudal gradient regarding progesterone receptors, which have a top thickness from receptors regarding head base, have commonly become claimed, and you will was confirmed by a number of publications.6061 Our selecting away from a predominance of prior skull ft meningiomas related to accessibility cyproterone acetate, a beneficial progestogen, are in line with such physiological findings.
Characteristics for the data
Numerous limits and concern the scientific and you may histological services regarding meningioma. SNDS does not have analysis on the outcome of magnetized resonance imaging or histology, or if meningiomas try unmarried otherwise several, with the exception of surgery one include distinctive line of anatomical regions.